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Concentrations of nandrolone metabolites in urine after the therapeutic administration of an ophthalmic solution swiss antidoping laboratory, university of lausanne, lausanne, switzerland 1. Introduction nandrolone, or 19-nortestosterone, is an anabolic steroid initially introduced for the treatment of anemia, osteoporosis and breast carcinoma. Deca (nandrolone) in particular is a very notorious anabolic steroid for a high rate and chance of detection, as one of the reasons is due to the fact that nandrolone’s metabolites in urine tend to remain for an excessively long period of time in the body in comparison to many other anabolic steroids. Nandrolone, also known as 19-nortestosterone or 19-norandrostenolone, is a semisynthetic anabolic-androgenic steroid derived from testosterone. Nandrolone is used in the form of a variety of long-acting prodrug esters for intramuscular injection, the most common of which are nandrolone decanoate. Nandrolone (durabolin) – 1 ng/ml urine in geldings, fillies, and mares, and for nandrolone metabolite (5a-oestrane-3β,17a-diol) – 45 ng/ml urine in male horses other than geldings. Testosterone – not greater than 20 ng/ml urine in geldings. The determination of nandrolone and its major metabolites in urine of a healthy volunteer is typically performed by fused-silica capillary column gas chromatography with electron impact quadropole mass spectrometry. A method to quantify metabolites of 17 -nandrolone (17 n) in boar and horse urine has been optimized and validated. Metabolites excreted in free form were extracted at ph 9. 5 with tert -butylmethylether. In june 2009, a ‘stable transfer’ urine sample was found to contain testosterone, at approximately 410 ng/ml, and its major metabolites, 3,17‐androstanediols. 2 interestingly, low levels of both boldenone and nandrolone (at approximately 2 ng/ml) were also identified in the sample. Once nandrolone has been metabolised, two major metabolites are excreted in urine, 19-norandrosterone (na) and 19-noretiocholanolone (ne). In 1997, in france, quite a few sportsmen had concentrations of 19-norandrosterone very close to the ioc cut off limit (2ng/ml). 19-nortestosterone (nandrolone) is an anabolic steroid compound widely used as a doping agent by athletes. The analysis of its urinary metabolites, 19-norandrosterone (na) and 19-noretiocholanolone (ne) glucuronides, allows the detection of surreptitious administration of nandrolone in sport. Hassager c, podenphant j, riis bj, johansen js, jensen j, christiansen c "changes in soft tissue body composition and plasma lipid metabolism during nandrolone decanoate therapy in postmenopausal osteoporoti women. " metabolism 38 (1989): 238-42. Urine extracts were analyzed by high-performance liquid chromatography/mass spectrometry (hplc/ms) to identify major metabolites and to determine their urinary excretion profiles. Major urinary metabolites, primarily glucuronide, conjugated and free, were detected for the selected steroids. “a doping offence for nandrolone was defined as a concentration of na in human urine exceeding 2 ng/ml in men and 5 ng/ml in women” when nandrolone is ingested or injected by humans subjects, three metabolites of nan- drolone can be isolated and measured in the urine by gas chromatography-mass spectrometry Aside from competing in bodybuilding, he also works as a fitness model and an occasional actor, nandrolone metabolites in urine. All orders are free of any shipping cost, nandrolone metabolites in urine.
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